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    Diosgenin

    Diosgenin

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    Diosgenin, a sapogenin, is the product of hydrolysis by acids, strong bases, or enzymes of saponins, extracted from the tubers of Dioscorea wild yam. The sugar-free (aglycone), diosgenin is used for the commercial synthesis of cortisone, pregnenolone, progesterone, and other products.

    Contents
    1 Sources
    2 Clinical Uses
    3 References
    4 External links

    Sources
    It is present in Costus speciosus, Smilax menispermoidea, species of Paris, Trigonella, and Trillium, and many species of Dioscorea - D. althaeoides, colletti, futschauensis, gracillima, hispida, hypoglauca, mexicana[1] nipponica, panthaica, parviflora, septemloba, and zingiberensis.[2]

    Clinical Uses
    Diosgenin is the precursor for the semisynthesis of progesterone[3] which in turn was used in early combined oral contraceptive pills.[4] The unmodified has estrogenic activity[5] and can reduce the level of serum cholesterol.[6]



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